|
KMID : 0545120050150020421
|
|
Journal of Microbiology and Biotechnology
2005 Volume.15 No. 2 p.421 ~ p.424
|
|
|
Expression of Newer Outer Membrane Proteins (OMPs) Induced by Cephalosporins and Quinolone Group of Antibiotics in Klebsiella pneumoniae
|
|
Vandana T
Sharma S/Chhibber S
|
|
|
Abstract
|
|
|
|
Effect of antibiotics belonging to three different groups including third generation cephalosporins aminoglycosides and quinolones on the outer membrane protein (OMP) profile of Klebsiella pneumoniae was examined. It was found that a new OMP (porins) of 40 kDa molecular mass was expressed in Klebsiella pneumoniae when grown in the presence of ceftazidime whereas new proteins with 30 kDa and 22 kDa masses were detected in the presence of ofloxacin. The immunoblot analysis showed that the new proteins of 40 kDa and 30 kDa molecular masses were expressed on the outer envelope when being exposed to antibiotics ceftazidime and ofloxacin respectively. This finding is important as the outer surface comes in contact with the immune system and therefore may have a bearing on the outcome of the disease.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|